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A method for on-line optimization of a fed-batch fermentation unit to maximize the product yield

Published online: Apr 27, 2009

Geographical region Europe
Subject Non-linear optimization techniques
Published date Apr 1, 2009
Title A method for on-line optimization of a fed-batch fermentation unit to maximize the product yield
Patent Application Number EP2041262 A1
Assignee ABB Research Ltd, Switzerland
Relevance A novel method for updating the model parameters for optimizing the substrate feed rate profile in a fed-batch fermentation unit to maximize the product yield via on-line optimization.
Type of claims Publication
Overview This patent discloses a novel method to calculate the optimum substrate feed rate based on real time plant data and updated model to maximize the product yield from the fed-batch fermentation process by non-linear optimization techniques. Advantageously, this method minimizes the modeling errors model, such that the model used in the optimization calculations is close to the real plant behavior. The method comprises, A) on-line measurement of plant parameters such as agitator speed, airflow rate, level measurement, sugar feed rate, percentage of carbon dioxide and oxygen in the vent gas and dissolved oxygen in the broth, B) storing of the on-line measurements/plant data as well as laboratory analysis results in a computer connected to the plant control system, C) fermenter model parameter re-estimation so as to reduce the mismatch between the plant data and the model calculation, D) on-line calculation of optimum sugar feed rate based on the current and past plant data so as to maximize the product yield.
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