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Altered glyoxylate shunt for improved production of aspartate-derived amino acids and chemicals

Published online: Apr 17, 2008

Geographical region Europe
Subject Production of aspartate-derived amino acids and chemicals
Published date Mar 19, 2008
Title Altered glyoxylate shunt for improved production of aspartate-derived amino acids and chemicals
Patent Application Number EP1899472 A1
Assignee Archer Daniels Midland Co, USA
Relevance A method of producing aspartate-derived amino acids and chemicals using recombinant microbial strain of Escherichia coli.
Type of claims Publication
Overview This patent discloses a method of production of L-amino acids by fermentation using bacterium (Escherichia coli) having improved properties comprising at least one gene in the aceBAK operon and/or a glcB gene that is regulated by a non-native promoter. The process involves, A) growing in a fermentation medium, a bacterium that produces the L-amino acid and that contains a recombinant nucleic acid construct operably configured to overexpress at least one gene selected from the group consisting of a gene in an aceBAK operon and a glcB gene in said bacterium, B) enriching L-amino acid in at least one of the fermentation medium and the bacterium and C) isolating L-amino acid from at least one of the fermentation medium and the bacterium.
Related patent documents US Patent publications

US6455284 - Metabolically engineered E.coli for enhanced production of oxaloacetate-derived biochemicals (2002)
US20030059903A1 - Process for the production of L-amino acids using strains of the family Enterobacteriaceae that contain an attenuated aceA gene (2003)
US5342766 - Process for producing L-threonine by fermentation with P. rettgeri (1994)
US5474918 - Process for the production of L-threonine and L-isoleucine by fermentation of Escherichia coli (1995)

Foreign patent publications

EP1408123 A1 - A microorganism in which the fadR gene is knocked out and a process for producing L-threonine using the microorganism (2004)
WO02081722 - Process for the production of L-amino acids using strains of the family Enterobacteriaceae that contain an attenuated ACEA gene (2002)
WO03038106A2 - A process for the production of L-amino acids using strains of the Enterobacteriaceae family which contain an enhanced FADR or ICLR gene (2003)
WO03008616 - process for the preparation of L-amino acids using strains of the Enterobacteriaceae family which contain an attenuated aceK gene (2003)

Patent Document Full Patent Document [external link]

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